Fracture after distraction osteogenesis.

Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis

Creating rigidly stabilized fractures for assessing intramembranous ossification, distraction osteogenesis, or healing of critical sized defects.

Assessing modes of skeletal repair is essential for developing therapies to be used clinically to treat fractures. Mechanical stability plays a large role in healing of bone injuries. In the worst-case scenario mechanical instability can lead to delayed or non-union in humans. However, motion can also stimulate the healing process. In fractures that have motion cartilage forms to stabilize the ...

Locally applied nerve growth factor enhances bone consolidation in a rabbit model of mandibular distraction osteogenesis.

Distraction osteogenesis is widely used in treating deformities, defects, and fractures of both long bones and craniofacial bones. Demands for acceleration of bone consolidation are increased in distraction osteogenesis. Nerve growth factor (NGF) can enhance innervation and bone regeneration in a fracture model and stimulate differentiation of osteoblastic cells. In this study, we tested the ab...

Long-term functional and quality of live assessment following post-traumatic distraction osteogenesis of the lower limb

Limb length discrepancy and segmental bone defects can be difficult problems to manage after fractures of the lower limb. Distraction osteogenesis can be applied to lengthen bone or to bridge intercalary defects by segmental bone transport. The purpose of this study was to assess the functional outcome and long-term quality of life after distraction osteogenesis of the lower limb when applied f...

Skeletal Repair in Distraction Osteogenesis: Mechanisms and Enhancements.

COPYRIGHT © 2015 BY THE JOURNAL OF BONE AND JOINT SURGERY, INCORPORATED » Distraction osteogenesis, utilized for reconstruction of skeletal deformities and bone defects, encompasses three phases of repair that are distinct from those of fracture-healing: latency, distraction, and consolidation. During distraction, osteogenic potential is maintained because of a number of molecular, cellular, an...

Parathyroid hormone PTH(1–34) increases the volume, mineral content, and mechanical properties of regenerated mineralizing tissue after distraction osteogenesis in rabbits

BACKGROUND AND PURPOSE Parathyroid hormone (PTH) has attracted considerable interest as a bone anabolic agent. Recently, it has been suggested that PTH can also enhance bone repair after fracture and distraction osteogenesis. We analyzed bone density and strength of the newly regenerated mineralized tissue after intermittent treatment with PTH in rabbits, which undergo Haversian bone remodeling...